An efficient synthesis of 3-substituted indole derivates under ultrasound irradiation.
نویسندگان
چکیده
A solvent-free procedure for the synthesis of 3-substituted indole derivates from indoles and nitroalkenes under ultrasound irradiation is described. Control experiments disclosed besides mechanical effects, namely agitation, sonochemical effects are the main forces to drive the reaction. In the method, 2-chloroethanol was used to prepare a wide variety of 3-substituted indole derivates. This procedure only need equimolar amounts of reaction substrates and can be readily scaled up.
منابع مشابه
Nano composite mixed-addenda vanadium substituted polyoxometalate-TiO2 as a green, reusable and efficient catalyst for rapid and efficient synthesis of symmetric disulfides under ultrasound irradiation
Mixed-addenda vanadium substituted polyoxometalate supported on anatase TiO2 crushed nano leaf was synthesized by an unusual reaction with titanium tetraisopropoxide at 100 ºC via sol–gel method under oil-bath condition. The materials characterized by XRD, TEM, IR and UV–vis techniques. In the present work, efficient oxidative of thiols with polyoxometalate-TiO2/hydrogen peroxide ...
متن کاملA Clean and Highly Efficient Synthesis of Oxindole Substituted Pyrrolo[2,3-d]Pyrimidines under Ultrasound Irradiation
A practical and new method for the synthesis oxindole substituted pyrrolo[2,3-d]pyrimidines by the condensation of isatin, acetophenone and 6-amino-uracil under ultrasound irradiation conditions at 60 °C was described. The reaction was developed via a sequential tandem process to afford the oxindole substituted pyrrolo[2,3-d]pyrimidines in good to excellent yields. All reactions performed effic...
متن کامل[BMIm]HSO4 as a Green and Highly Efficient Catalyst for One-pot Synthesis of 3-Substituted Indoles under Ultrasound Irradiation
A practical and green synthesis of 3-substituted indoles is reported via three-component coupling reaction of indoles, aldehydes and N-methylaniline in the presence of the acidic ionic liquid 1-butyl-3-methylimidazolium hydrogen sulfate ([BMIm]HSO4) under ultrasound irradiation at room temperature. The significant features of this procedure are high yields of the products, simple work-up, opera...
متن کاملGraphene–ZnO@SiO2 hybrid: An efficient and solid acid catalyst for synthesis of azlactones under ultrasound irradiation
The central theme of this article is how to explore a novel route to fabricate graphene– ZnO@SiO2 hybrid by a covalent process. The synthesis procedure consists of three-steps: (1) synthesis of ZnO nanoparticles, (2) ZnO nanoparticles modification by tetraethyl orthosilicate and (3-aminopropyl) triethoxysilane after introduction of amino groups on its surface, (3) the covalent attach...
متن کاملGraphene–ZnO@SiO2 hybrid: An efficient and solid acid catalyst for synthesis of azlactones under ultrasound irradiation
The central theme of this article is how to explore a novel route to fabricate graphene– ZnO@SiO2 hybrid by a covalent process. The synthesis procedure consists of three-steps: (1) synthesis of ZnO nanoparticles, (2) ZnO nanoparticles modification by tetraethyl orthosilicate and (3-aminopropyl) triethoxysilane after introduction of amino groups on its surface, (3) the covalent attach...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Ultrasonics sonochemistry
دوره 18 2 شماره
صفحات -
تاریخ انتشار 2011